We take multiple shots in hopes of scoring a goal. We can now begin with a gene that we believe relates to a particular disease, then either increase or suppress the activity of that gene in the hope of discovering its precise role in that particular condition. That’s the classic pharmacological approach.Īnother, newer approach is based on knowledge we’ve gained during the genomic revolution. Scientists would then tweak the chemical or molecule to make it safe and effective in humans. ![]() Nowhere is that sense of optimism more needed than in drug discovery, which seeks to identify and develop potential medicines that provide a favorable and delicate balance of effectiveness against disease while ensuring safety.Ī: Thirty or more years ago, the discovery of new medicines was based on the observation that a chemical or an herbal extract had a biological effect. Can you elaborate?Ī: Don Quixote relied on imagination, determination, and luck, and researchers need all three to prevail-along with an unwavering sense of optimism in the face of ongoing defeat. Q: You’ve likened the researcher’s path of discovery to Don Quixote’s quest.
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